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Eli Lilly and Co. is expanding its investment in Indiana’s LEAP Research and Innovation District in Lebanon, Ind., with the $4.5 billion development of the Lilly Medicine Foundry, the first facility to combine research and manufacturing in one location. With the addition of the Medicine Foundry, Lilly’s investment at the site will exceed $13 billion.

The facility will give the Indianapolis-based company the ability to research new ways of producing medicines, while also scaling up production for clinical trials. It is slated to open in late 2027 and is expected to add 400 full-time jobs for highly skilled workers including engineers, scientists, operations personnel and lab technicians.